MBBS BSc (Hons) FRCPCH

Tammy Hedderly is an acute paediatric neurologist working at Evelina London Children’s Hospital (Guys and St Thomas’) and is also an Adjunct Reader at Kings College, London.

She was elected Vice-Chair of ESSTS in June 2023. She covers an general neurology service and has an interest in paediatric movement disorders, brain injuries and neuropsychology. She has a sub-speciality interest in the link between movement disorders, cognition and neuro-psychiatry. She developed and leads a national service called TANDeM,a multi-disciplinary service for children with Tics, Tourette’s, Stereotypies, functional neurological disorders and Paroxysmal dyskinesias.  She runs a diagnostic and management service for children with Autism Spectrum and Wilsons Disease. Working in collaboration with neurologists and psychiatrists across Europe within ESSTS and with colleagues across the USA, TH participates in several large-scale research projects studying the role of genetics, infections, immunology and other environmental factors in some of these complex disorders. With her team, TH has presented and described novel clinical phenomenology in movement disorders such as ‘Intense Imagery Movements’ and ‘Tic-like Attacks’ and more recently functional tic like movements’.

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Selection of  Recent Journal Publications

Fotis Tsetsos et al Genome-wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome, Biologica lPsychiatry, 2023 ISSN0006-3223.

https://doi.org/10.1016/j.biopsych.2023.01.023

Cross-Disorder Group of the Psychiatric Genomics Consortium.

Electronic address:plee0@mgh.harvard.edu; Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across

Eight Psychiatric Disorders. Cell. 2019 Dec 12;179(7):1469-1482.e11.

doi: 10.1016/j.cell.2019.11.020.PMID: 31835028; PMCID: PMC7077032.

Szejko N, RobinsonS, Hartmann A, Ganos C, Debes NM, Skov L, Haas M, Rizzo R, Stern J, Münchau A, Czernecki V, Dietrich A, Murphy TL, Martino D, Tarnok Z, Hedderly T, Müller-Vahl KR, Cath DC. European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment. Eur Child

Adolesc Psychiatry.2022 Mar;31(3):383-402.

doi: 10.1007/s00787-021-01842-2.

Epub 2021 Oct 18.PMID: 34661764; PMCID: PMC8521086.

Pringsheim T, GanosC, McGuire JF, Hedderly T, Woods D, Gilbert DL, Piacentini J, DaleRC, Martino D. Rapid Onset Functional Tic-Like Behaviors in

Young FemalesDuring the COVID-19 Pandemic. Mov Disord. 2021 Dec; 36(12):2707-2713.doi: 10.1002/mds.28778. Epub 2021 Aug 31. PMID: 34387394;

PMCID: PMC8441698.

Heyman I, Liang H, Hedderly T. COVID-19 related increase in childhood tics and tic-like attacks. Arch Dis Child. 2021 Mar 6:archdischild-2021-321748.

doi: 10.1136/archdischild-2021-321748.Epub ahead of print. PMID: 33677431.

Hollis C, PennantM, Cuenca J, Glazebrook C, Kendall T, Whittington C, Stockton S, LarssonL, Bunton P, Dobson S, Groom M, Hedderly T, Heyman I, Jackson GM, JacksonS, Murphy T, Rickards H, Robertson M, Stern J. Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and

qualitative analysis. Health Technol Assess. 2016 Jan;20(4):1-450, vii-viii.

doi:10.3310/hta20040. PMID: 26786936; PMCID: PMC4781241.

Tang S, Addis L, SmithA, Topp SD, Pendziwiat M, Mei D, Parker A, Agrawal S, Hughes E, LascellesK, Williams RE, Fallon P, Robinson R, Cross HJ, Hedderly T, Eltze C, Kerr T,Desurkar A, Hussain N, Kinali M, Bagnasco I, Vassallo G, Whitehouse W, GoyalS, Absoud M; EuroEPINOMICS-RES Consortium, Møller RS, Helbig I, Weber YG, MariniC, Guerrini R, Simpson MA, Pal DK. Phenotypic and genetic spectrum of epilepsy with myoclonic atonic seizures. Epilepsia. 2020

May;61(5):995-1007.doi: 10.1111/epi.16508. Epub 2020 May 29. PMID: 32469098.

Martino D, HedderlyT. Tics and stereotypies: A comparative clinical review.

Parkinsonism RelatDisord. 2019 Feb;59:117-124.

doi: 10.1016/j.parkreldis.2019.02.005.Epub 2019 Feb 4. PMID: 30773283.

Bhatoa RS, Malik O,Robinson S, Hedderly T. Clinical management of complex motor stereotypies. Arch Dis Child. 2021 Nov 1:archdischild-2021-322624.

doi: 10.1136/archdischild-2021-322624.Epub ahead of print. PMID: 34725047.

Abdulkadir M, Yu D,Osiecki L, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ,Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, HuyserC, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B,Madruga-Garrido M, Maras A, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V,Shin EY, Song DH, Song J, Visscher F, Zinner SH, Mathews CA, Scharf JM,Tischfield JA, Heiman GA, Dietrich A, Hoekstra PJ. Investigation of gene-environment interactions in relation to tic severity. J Neural Transm

(Vienna). 2021Nov;128(11):1757-1765. doi: 10.1007/s00702-021-02396-y. Epub 2021 Aug 13. PMID:34389898; PMCID: PMC8536549.

Tsetsos F et al Synapticprocesses and immune-related pathways implicated in Tourette syndrome. TranslPsychiatry. 2021 Jan 18;11(1):56.doi: 10.1038/s41398-020-01082-z. PMID: 33462189; PMCID: PMC7814139.

Hedderly T, MalikO. Childhood Acute Neuropsychiatric Syndromes…furthering the discussion PANSand PANDAS. Eur J Paediatr Neurol. 2018 Mar;22(2):223-224.

doi:10.1016/j.ejpn.2018.01.022. PMID: 29447768.

Horner O, HedderlyT, Malik O. The changing landscape of childhood tic disorders followingCOVID-19. Paediatr Child Health (Oxford). 2022

Oct;32(10):363-367.doi: 10.1016/j.paed.2022.07.007. Epub 2022 Aug 9. PMID: 35967969; PMCID: PMC9359930.

Buts S, Duncan M,Owen T, Martino D, Pringsheim T, Byrne S, McWilliams A, Murphy T, Malik O,Liang H, Heyman I, Hedderly T. Paediatric tic-like

presentationsduring the COVID-19 pandemic. Arch Dis Child. 2022 Mar;107(3):e17.

doi:10.1136/archdischild-2021-323002. Epub 2021 Nov 25. PMID: 34824091.

Pfeiffer HCV,Wickstrom R, Skov L, Sørensen CB, Sandvig I, Gjone IH, Ygberg S, de Visscher C,Idring Nordstrom S, Herner LB, Hesselmark E, Hedderly T, Lim M, Debes NM.Clinical guidance for diagnosis and management of suspected Pediatric Acute-onset Neuropsychiatric Syndrome in the Nordic countries. Acta Paediatr. 2021Dec;110(12):3153-3160. doi: 10.1111/apa.15875. Epub 2021 May 6.

PMID: 33848371.

Addabbo F, BaglioniV, Schrag A, Schwarz MJ, Dietrich A, Hoekstra PJ, Martino D,Buttiglione M; Emtics Collaborative Group. Anti-dopamine D2 receptor antibodies in chronic tic disorders. Dev Med Child Neurol. 2020 Oct;62(10):1205-1212.doi: 10.1111/dmcn.14613. Epub 2020 Jul 9. PMID: 32644201.

Cao X, et al Whole-exomesequencing identifies genes associated with Tourette's disorder in multiplex families.Mol Psychiatry. 2021 Nov;26(11):6937-6951.

doi: 10.1038/s41380-021-01094-1.Epub 2021 Apr 9. PMID: 33837273; PMCID: PMC8501157.

Mehra C, Sil A,Hedderly T, Kyriakopoulos M, Lim M, Turnbull J, Happe F, Baird G, Absoud M. Childhood disintegrative disorder and autism spectrum disorder: a systematic review. Dev Med Child Neurol. 2019 May;61(5):523-534.

doi: 10.1111/dmcn.14126.Epub 2018 Dec 13. PMID: 30548847.