
A long-awaited episode with Professor Stephen Jackson and Dr Barbara Morera from the University of Nottingham and Neurotherapeutics Ltd.
They have been developing "a safe and effective non-drug treatment that reduces tics and the urge to tic, through gentle stimulation of the median nerve in the wrist".
We are grateful to them for taking the time to answer very important questions that help us understand the effect of median nerve stimulation on tic suppression.
Please find below the questions addressed and key points of our conversation.
- Why is non-invasive stimulation of interest in the pathophysiological mechanism of tic generation?
- How did the idea of using peripheral stimulation in modulating cortical motor excitability in tics occur?
- When exploring the effect of median nerve stimulation on tic suppression in your study, what was your methodology (in terms of number of participants, inclusion criteria e.g. comorbidities, time and recurrence of stimulation, assessment of efficacy)?
- What did it show? Did the MNS lead to a statistically significant reduction of tics?
- Is MNS supposed to work only during stimulation?
- You showed that rhythmic but not arrhythmic trains of MNS lead to entrainment of 12 Hz oscillations and are of interest in tic reduction, is that right? How would you interpret this result?
- In your work, tic intensity and tic frequency were studied:
- What scale did you use?
- Did you distinguish vocal tics and motor tics?
- Did the participants have particularly severe forms of TS?
- How did you demonstrate that these results are not only the effects of distraction?
- What is the effect of MNS of volitional movements and cognitive function?
- Who would benefit the most from MNS? / For what use in real life would MNS be useful? Both for children and adults?
- What do people feel when receiving this stimulation? Is it painful, irritating, annoying, strange?
- Does MNS have a main effect or PU or tics? Are we able to know at this point
- Is there a study planned with a larger sample or another objective?
- Is there another use of MNS in movement disorders?
- When do you think it will be available on the market? At what price?
Stephen Jackson is Professor of Cognitive Neuroscience at the University of Nottingham and Director of the University’s Centre for Neuromodulation, Neurotechnology, and Neurotherapeutics.
He is a co-founder of Neurotherapeutics Ltd, a university medical device spin-out established in 2021 to develop a wearable for of non-invasive brain stimulation (the Neupulse device) for the treatment of tic disorders. His current research focuses on developing non-invasive brain stimulation treatments for a range of brain disorders and mental health conditions.
Dr Barbara Morera is a neuroscientist who has been working with Prof. Stephen Jackson on the development of a non-invasive treatment for Tourette Syndrome and Chronic Tic Disorder for the last 8 years. Co-founder of the company Neurotherapeutics, a spin out company from the University of Nottingham, founded with the aim to make this treatment available for those who would like to control their tics.
You are more than welcome to get in touch with them directly!
Contact Stephen Jackson and Barbara Morera
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The Frontiers editorial office will be able to provide more information/answer any questions.
Discover the spectacular destination where we shall meet again next summer!



Invited speakers
- Le relazioni si terranno in lingua inglese con traduzione simultanea in italiano
- Accreditamento ECM per medici, psicologi, infermieri
"A brilliant and empathetic comedy narrating the daily life of a boy with Tourette."
(See detailed programme below)
- Prof Andreas Hartmann, France
Neurologist, Department of Neurology, Hôpital de la Pitié-Salpêtrière, Paris, FR - Dr Christelle Nilles, France
Neurologist, Department of Neurology, Rothschild Foundation Hospital, Paris, FR
- Michele Dunlap, Germany
President & Acting Treasurer - Marla Shea, UK/USA
Secretary
- Christina Papakaliatis, Founder
-Healthcare professionals: a round table for discussion with the speakers will be held in the afternoon.
Online registration is mandatory to secure your participation.
- This event is strictly available to adults and minors aged 16-17 years old. Underaged attendees will not be permitted access.
- The seminar is offered for educational purposes; clinical consultations with any of the invited healthcare professionals will not be provided onsite.
- Only registered participants may attend the event. We will regrettably not be able to admit other non-registered visitors accompanying you.
- Tourette Greece
- TTAG
- ESSTS
- Assessment (including differential diagnosis)
- Natural course and prognosis
- Epidemiology
- Causes & mechanisms
- Q&A
- ADHD (Attention Deficit Hyperactivity Disorder)
- OCD (Obsessive-Compulsive Disorder)
- ASD (Autism Spectrum Disorder)
- Mood (anxiety & depression)
- Sleep
- Q&A
- Available treatments
- Clinical cases
- Comprehensive Q&A with the audience
- Tuesday, 27 May 2025: 18:00-20:00 GMT. Led by: Virginie Czernecki & Katrin Woitecki
- Tuesday, 30 September 2025: 18:00-20:00 GMT. Led by Tara Murphy & Jolande van de Griendt
- Tuesday, 25 November 2025: 18:00-20:00 GMT. Led by: Cara Verdellen & Katrin Woitecki
Registration rate per online consultation (2 hours): €35.
(See detailed programme below)
- Dr Christos Androutsos
Child and Adolescent Psychiatrist
Head Consultant at the Child and Adolescent Psychiatry Department, SGHA - Dr Anastasia Dougali
Child and Adolescent Psychiatrist
Child and Adolescent Psychiatry Department, SGHA
- Dr Marinos Kyriakopoulos
Child and Adolescent Psychiatrist
Assistant Professor in Child and Adolescent Psychiatry
- Athanasia Makri
Psychologist
MSc in Clinical Psychology
Online registration is mandatory to secure your participation.
- This event is strictly available to adults and minors aged 16-17 years old. Underaged attendees will not be permitted access.
- The seminar is offered for educational purposes; clinical consultations with any of the invited healthcare professionals will not be provided on site.
- Only registered participants may attend the event. We will regrettably not be able to admit other non-registered visitors accompanying you.
- Behavioural approaches being adapted for acceptance – developmental factors
- Working with school, work & family
- Using Schema Therapy techniques to deal with negative childhood experiences that need addressing
- Parents Living Well with Tics; engaging the system to enhance acceptance and well being
Case discussion led by Noa Ben-Aroya, Dana Feldman and John Piacentini